PD in the News
Researchers Develop New, Working Mammalian Model To Combat Genetic Causes Of Parkinson's
Evidence is steadily mounting that genetic factors play an important role in many cases of Parkinson's disease (PD). In a study published February 2, 2011, online in the Journal of Neuroscience, researchers from the Ecole Polytechnique Federale de Lausanne (EPFL) in Switzerland report a new mammalian model for studying a specific gene mutation commonly found in PD sufferers, opening the door to new drugs to fight the malady.
Discovery Of A Possible Cause Of Parkinson's Disease
"Nucleolus", or small nucleus, is the term coined by early biologists for the tiny structure within the nucleus which they saw under the microscope. In this structure within the nucleus, RNA molecules and proteins are assembled to form ribosomes, the true protein factories of cells.
Eleven Genetic Variants Now Linked To Parkinson's After Global Research
In the largest genetic analysis of Parkinson's disease ever, now a total of 11 genetic variants have been discovered as related causes of the crippling disease which to date, has no cure. These variants were defined from a pool of 7.
Researchers Identify 5 New Genetic Variations In Total Of 11 Thought To Be Important In Parkinson's Disease Risk
Until recently, environmental factors were thought to be wholly responsible for Parkinson's disease (PD). Since 2007 six genetic variants or 'loci' have been implicated that affect risk of developing the condition.
Unfolding Pathogenesis In Parkinson's; Breakthrough Suggests Damaged Proteins Travel Between Cells
The misfolding of abnormal proteins in brain cells is a key element in Parkinson's disease development. A recent study suggests that the sick proteins slowly move between cells, eventually triggering the destruction of the new host cell.
NeuroSearch Sweden AB: Next Steps To Treat Parkinson's, Huntington's And Alzheimer's Disease
Joachim Tedroff, Head of Clinical Science at NeuroSearch Sweden AB, joined Pharma IQ to discuss Optimising Clinical Development in CNS. He discussed compound ACR16 or pridopidine, which is a generic name, that was developed in Carlsson Research about ten years ago.
EyeBrain Announces Availability Of Its Eye-Tracking Device For Earlier Diagnosis Of Parkinson-Plus Diseases
EyeBrain, a developer of medical devices for the early diagnosis of neurological diseases, today announced that its eye-tracking system (Mobile Eye Brain Tracker or Mobile EBT) is now available on the market for the detection of Parkinson-plus diseases.
Discovering The Brain's Secrets: From Addiction To Disease, Australia
The most complicated human organ goes under the microscope in Auckland later this month with the world's leading brain researchers arriving to attend the annual Australian Neuroscience Society (ANS) Conference.
Unfolding Amyloid Secrets
Scientists from the University of Leeds have made a fundamental step in the search for therapies for amyloid-related diseases such as Alzheimer's, Parkinson's and diabetes mellitus. By pin-pointing the reaction that kick-starts the formation of amyloid fibres, scientists can now seek to further understand how these fibrils develop and cause disease.
Progress In The Development Of New Parkinson's Drugs
The side effects of the standard medication for Parkinson's disease have long been a preoccupation of brain researchers. Now Daniella Rylander has presented new findings in a recently defended PhD thesis at Lund University that provide hope of more effective medication for those who suffer from the nerve cell disease.
Scientists Say Frontal Lobe Of The Brain Is Key To Automatic Responses To Various Stimuli
Some people may excel at riding a bike, tying a tie, or playing the piano, but those same people may find it difficult to explain or teach those skills to someone else.These motor skills are learned in one part of the brain, whereas classroom instruction and information read in a book are acquired in another area of the brain, explained.
A Step Closer To A Cure For Parkinson's Disease
An international collaboration led by academics at the University of Sheffield, has shed new light into Parkinson's disease, which could help with the development of cures or treatments in the future.
New Regulator Of Circadian Clock Identified
Daily sleeping and eating patterns are critical to human well-being and health. Now, a new study from Concordia University has demonstrated how the brain chemical dopamine regulates these cycles by altering the activity of the "clock-protein" PER2.
Davis Phinney Foundation Launches Exercise-Focused Tools To Help People Live Well With Parkinson's Disease
The Davis Phinney Foundation, a non-profit foundation whose mission is to provide information and tools that help people to live well with Parkinson's disease, announced the availability of a new exercise DVD: "Exercise and Parkinson's: Questions and Answers from the Experts.
Ceregene Initiates A New Controlled Phase 2b Trial Of CERE-120 For Parkinson's Disease
Ceregene, Inc., a biopharmaceutical company, announced that enrollment has begun in a new double-blind sham surgery-controlled Phase 2b study evaluating CERE-120 in Parkinson's disease patients.
Use Of Deep Brain Stimulation To Treat Parkinson's: Researchers Reach Consensus
Since the late 1990s, deep brain stimulation (DBS) has proven to be a lifeline for some patients suffering from Parkinson's disease, a cruel neurological disorder that can cause lack of control over movement, poor balance and coordination, and rigidity, among other symptoms.
Santhera And Ipsen Enter Into Licensing Agreement For Fipamezole For The Treatment Of Dyskinesia In Parkinson's Disease
Santhera Pharmaceuticals (SIX: SANN) and Ipsen (Paris:IPN) (Euronext: IPN; ADR: IPSEY) announced a license agreement for the development and commercialization of fipamezole (antagonist of the adrenergic alpha-2 receptor) for territories outside of North America and Japan.
New Light On The Mechanism Of Parkinson's Disease
A significant number of Parkinson's disease patients have a mutation of the enzyme Leucine-Rich Repeat Protein Kinase 2 (LRRK2, also known as dardarin). However, little is understood about how it is regulated or functions.
New Parkinson's Gene Is Linked To Immune System
A hunt throughout the human genome for variants associated with common, late-onset Parkinson's disease has revealed a new genetic link that implicates the immune system and offers new targets for drug development.
Impax Pharmaceuticals Completes Enrollment In ADVANCE-PD Phase III Trial Of IPX066 In Parkinson's Disease
Impax Pharmaceuticals, the brand products division of Impax Laboratories, Inc. (NASDAQ: IPXL), announced that it has completed enrollment of its ADVANCE-PD trial. ADVANCE-PD is a multinational Phase III trial of its late-stage product IPX066 in advanced Parkinson's disease (PD) patients with motor fluctuations.
Alnylam And Collaborators Publish New Pre-Clinical Research On Therapeutic Silencing Of Parkinson's Disease Gene
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and collaborators at The Parkinson's Institute and the Mayo Clinic have published new research findings in the journal Public Library of Science (PLoS).
A Promising Target For Developing Treatments Against Parkinson's Disease
Researchers at Johns Hopkins have shown that using specific drugs can protect nerve cells in mice from the lethal effects of Parkinson's disease. The researchers' findings are published in the August 22 issue of Nature Medicine.
Parkinson's disease patients find benefits in martial arts exercise
A form of martial arts - tai chi - is being used as a means of defense against an internal opponent - Parkinson's disease.
Study: Parkinson's Linked To Immune System
North Country Gazette
The study, “Common Genetic Variation in the HLA Region is Associated with Late-onset Sporadic Parkinson's disease,” conducted by the NeuroGenetics Research
Immune System Genes Linked To Parkinson's Disease
An international team of researchers conducting a genome-wide association study (GWAS) has discovered that common variants in immune system genes are linked to Parkinson's disease. The study was the work of the NeuroGenetics Research Consortium, led by Dr Haydeh Payami, a research scientist at the Health Wadsworth Center and professor in the School of Public Health, both in the New York State Department of Health.
Genetic Link Discovered Between Immune System, Parkinson's Disease
A team of researchers has discovered new evidence that Parkinson's disease may have an infectious or autoimmune origin. "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease" appears online in Nature Genetics.
Brain Connections Break Down As We Age
It's unavoidable: breakdowns in brain connections slow down our physical response times as we age, a new study suggests.This slower reactivity is associated with an age-related breakdown in the corpus callosum, a part of the brain that acts as a dam during one-sided motor activities to prevent unwanted connectivity, or cross-talk, between the two halves of the brain, said Rachael Seidler, associate professor in the University of Michigan School of Kinesiology and Department of Psychology, and lead study author.
TEMPO Study Further Demonstrates The Benefits Of Azilect® In Early Parkinson's Disease Patients
H. Lundbeck A/S (Lundbeck) and Teva Pharmaceutical Industries Ltd. (NASDAQ: TEVA) announced newly published long-term data on Azilect® (rasagiline tablets) from the TEMPO study and its open-label extension.
Expectations May Affect Placebo Response In Patients With Parkinson's Disease
Individuals with Parkinson's disease were more likely to have a neurochemical response to a placebo medication if they were told they had higher odds of receiving an active drug, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
Study Identifies Molecular Mechanism Triggering Parkinson's Disease
Scientists at the Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. This discovery not only may explain how a genetic mutation linked to Parkinson's causes the cells' death, but could also open the door to new therapeutic approaches for the malady.
New Pathway To Parkinson's And Alzheimer's Diseases
Although their genetic underpinnings differ, Alzheimer's disease, Parkinson's disease and Huntington's disease are all characterized by the untimely death of brain cells. What triggers cell death in the brain? According to a new study published by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) in the July 30 issue of Molecular Cell, the answer in some cases is the untimely transfer of a gaseous molecule (known as nitric oxide, or NO) from one protein to another.
Study Identifies Molecular Mechanism Triggering Parkinson's Disease
Scientists at the Stanford University School of Medicine have identified a molecular pathway responsible for the death of key nerve cells whose loss causes Parkinson's disease. This discovery not only may explain how a genetic mutation linked to Parkinson's causes the cells' death, but could also open the door to new therapeutic approaches for the malady.
Proteins Play Role In Massive Neuron Death
A team of researchers, led by scientists at the University of California, San Diego, have identified a key player in the dramatic loss of neurons in mice and fly models, a discovery that could help illuminate the role of mitochondrial dysfunction in human neurodegenerative disorders, such as Parkinson's disease.
The Michael J. Fox Foundation Awards $2.5 Million To Support Ceregene's New Phase 2 Neurturin Clinical Study For Parkinson's Disease
The Michael J. Fox Foundation for Parkinson's Research (MJFF) will provide $2.5 million to support Ceregene Inc.'s new Phase 2 study of CERE-120. This novel gene therapy product delivers the gene for neurturin, a potent neurotrophic (growth) factor that has shown potential to improve the status of degenerating neurons in both preclinical and clinical studies.
Tests Help Predict Falls In Parkinson's Disease
A group of tests may help predict which people with Parkinson's disease are more likely to fall, according to a study published in the June 23, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Explaining Parkinson's Patients' 'Risky Behavior'
Scientists at UCL (University College London) have explained Parkinson's patients' risky behaviour, a rare side effect of standard treatments for the disease. The finding has implications for future medication of patients.
MedGenesis And Biovail Announce Grant From The Michael J. Fox Foundation For The Development Of GDNF
MedGenesis Therapeutix Inc. and Biovail Corporation (TSX:BVF)(NYSE:BVF) announced that The Michael J. Fox Foundation (MJFF) for Parkinson's Research has awarded a $2.1 million USD grant to MedGenesis Therapeutix Inc.
Neurologix Announces Successful Phase 2 Trial Of Gene Therapy For Parkinson's Disease
Neurologix, Inc. (OTC Bulletin Board: NRGX), announced positive results in a Phase 2 trial of its investigational gene therapy for advanced Parkinson's disease (PD), NLX-P101. Study participants who received NLX-P101 experienced statistically significant and clinically meaningful improvements in off-medication motor scores compared to control subjects who received sham surgery.
Using Argonne's Supercomputer To Drive Discovery And Innovation
The Argonne Leadership Computing Facility (ALCF), located at the U.S. Department of Energy's (DOE) Argonne National Laboratory, has run over two billion processor-hours of computations at a mind-boggling speed of over 557 trillion calculations a second as it enables scientists and engineers to conduct cutting-edge research in just weeks or months rather than years.
Improving Understanding Of Protein Folding
Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate biological processes associated with diseases such as Alzheimer's and Parkinson's.
Genes And Pesticide Exposure Interact To Increase Men's Risk For Parkinson's Disease
Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.
New Study Showed The Impact Of Gastrointestinal Disorders In Patients With Parkinson's Disease
New data from a retrospective cohort study showed that up to three quarters of patients with Parkinson's disease (PD) developed gastrointestinal disorders (GID) that can have a substantial adverse effect on major PD-related clinical and health economic outcomes.
UC San Diego Researchers Say Over-Abundant Protein Shuts Down Cell Communications, Helps Cause Dementia
In diverse neurodegenerative diseases ranging from Parkinson's to Alzheimer's, researchers have long noted accumulations of a little-understood neuronal protein called Î±-synuclein. Pathological and genetic evidence strongly suggested that excessive a-synuclein played a role in the evolution of these diseases, but it was unclear how too much a-synuclein culminated in synaptic damage and neurodegeneration.
Addex's ADX48621 Effective In Preclinical Parkinson's Disease Studies
Allosteric modulation company Addex Pharmaceuticals Ltd (SIX: ADXN) presented encouraging data from preclinical studies demonstrating the anti-Parkinson's effects of ADX48621, a novel drug candidate that has completed three Phase I clinical trials.
Nerve Cells In Parkinson's Disease Suffer Communication Breakdown
A new study from The Montreal Neurological Institute and Hospital - The Neuro - at McGill University is the first to discover a molecular link between Parkinson's disease and defects in the ability of nerve cells to communicate.
Parkinson's Patients May Benefit From Spinal Cord Stimulation
A new study from Rhode Island Hospital indicates that spinal cord stimulation may be able to modulate Parkinson's disease symptoms. The lead author is presenting the findings at the 2010 American Society for Stereotactical and Functional Neurosurgery (ASSFN) Biennial Meeting, June 14-16 in New York City.
Sense Of Smell Holds The Key To Diagnosis And Treatment In Early Stage Parkinson's Disease
A fast, simple and non invasive test of the ability to smell may be an important tool to screen people who are likely to develop Parkinson's disease (PD), in which motor symptoms only become evident at a later stage of the disease, a German scientist will tell the annual conference of the European Society of Human Genetics today (Saturday).
VA Research Offers Insight On Parkinson's Disease
Veterans and others with Parkinson's disease who undergo deep brain stimulation (DBS) may benefit from research co-sponsored by the Department of Veterans Affairs and published recently in the prestigious New England Journal of Medicine.
Recently Published Clinical Pharmacology Study Confirms Azilect(R) Selectively Inhibits MAO-B At Approved Doses
Teva Neuroscience Inc. announced the publication of a study demonstrating the selectivity of Azilect® (rasagiline tablets) for inhibition of MAO-B (monoamine oxidase-B) at the maximum approved dose of 1 mg/day.
Industrial Cleaner Linked To Increased Risk Of Parkinson's Disease
Workers exposed to tricholorethylene (TCE), a chemical widely used to clean metal such as auto parts, may be at a significantly higher risk of developing Parkinson's disease, according to a study released today that will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010.
The Quick And The Dead: Evidence That Movement Is Swiftest In Response To Events In The Environment
Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust at the University of Birmingham have carried out "laboratory gunfights" to show that we move faster when we react to something in our environment than we do when we initiate the action ourselves- an idea inspired by cowboy movies but in reality more useful for avoiding oncoming traffic.
Parkinson's Disease Research Uncovers Social Barrier
People with Parkinson's disease suffer social difficulties simply because of the way they talk, a McGill University researcher has discovered. Marc Pell, at McGill's School of Communication Sciences and Disorders, has learned that many people develop negative impressions about individuals with Parkinson's disease, based solely on how they communicate.
Simulation Study May Help Parkinson's Patients Retain Driving Skills
In a first-of-its-kind study, Medical College of Georgia researchers are testing whether simulation driving can reduce Parkinson's patients' threefold increased risk of car accidents.Drivers with Parkinson's disease are three times more likely to have a car accident than healthy drivers because of cognitive, motor and visuospatial impairments.
Gordon Brown Receives Prescription Promise 'Wake-Up Call', UK
People across England will be joining forces to demonstrate their outrage at Gordon Brown's failure to act on his promise to abolish prescription charges for people with long-term conditions, by taking part in a simultaneous 'wake-up phone call' to No 10.
Synosia Announces Positive Interim Results For Potential First-in-Class Treatment For Parkinson's Disease
Synosia Therapeutics announced interim positive data from a Phase IIa clinical study of an adenosine 2a (A2a) receptor antagonist (SYN115) in Parkinson's disease. The Phase IIa trial was a randomised, double-blind, placebo-controlled, cross-over study in 24 Parkinson's patients using doses up to 120mg/day for one week.
Parkinson's Rates Highest In Whites, Hispanics
The largest epidemiological study of Parkinson's disease in the United States has found that the disease is more common in the Midwest and the Northeast and is twice as likely to strike whites and Hispanics as blacks and Asians.
Lefkowitz, BBVA Foundation Frontiers Of Knowledge Award In Biomedicine
The BBVA Foundation Frontiers of Knowledge Award in the Biomedicine category goes in this second edition to Prof. Robert J. Lefkowitz (1943, New York, United States), investigator in the Department of Medicine at Duke University (United States).
'Deep Brain Stimulation' For Parkinson's Disease: Study By Scott & White Healthcare Researchers
At Scott & White Memorial Hospital, a multi-disciplinary team of neurosurgeons, neurologists, neurophysiologist, neuropsychologists and a movement disorders specialist are offering hope to some Parkinson's patients with a treatment called Deep Brain Stimulation (DBS).
Study Finds Common Heart Medications May Also Protect Against Parkinson's Disease
UCLA researchers have discovered that a specific type of medication used to treat cardiovascular conditions such as hypertension, angina and abnormal heart rhythms may also decrease the risk of developing Parkinson's disease.
A Novel Brain-based Computational Model Of How Parkinson's Disease And Dopamine Medications Affect Learning And Attention
A new brain-based computational model is helping to understand how Parkinson's disease and dopamine medications - used to treat motor symptoms caused by the disease - can affect learning and attention.
In Parkinson's Patients Brain Abnormalities Develop Before Symptoms Occur
Scientists who have identified brain networks damaged in Parkinson's disease have new evidence that these systems become abnormal a few years before symptoms appear. And what's more, parts of the network appear to respond in a last ditch attempt to rescue the brain.
Treadmill Training Improves Movement In Parkinson's Patients
Treadmill training can be used to help people with Parkinson's disease achieve better walking movements, say researchers. In a systematic review of the evidence, Cochrane Researchers concluded treadmill training could be used to improve specific gait parameters in Parkinson's patients.
Staring, Sleepiness, Other Mental Lapses More Likely In Patients With Alzheimer's
Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are developing Alzheimer's disease than in their healthy peers, according to scientists at Washington University School of Medicine
Genetic Risk Factor Identified For Parkinson's Disease: Gene Variant Influences Vitamin B6 Metabolism
An international team of doctors and human geneticists has identified a new genetic risk factor for Parkinson's disease. The institutions involved in the study were the Institute of Human Genetics of Helmholtz Zentrum MÃ¼nchen and Technische UniversitÃ¤t MÃ¼nchen, the Neurological Clinic of Ludwig-Maximilians-UniversitÃ¤t Munich (LMU) and the Mitochondrial Research Group of Newcastle University, Newcastle upon Tyne, UK.
Parkinson's Patients Who Are Pathological Gamblers Also Display Abnormal Social Behaviour
People with Parkinson's Disease are more likely to display abnormal social behaviour and make poor decisions in ambiguous circumstances if they are pathological gamblers, according to research in the January issue of the European Journal of Neurology.
A New Paradigm And New Drugs For Parkinson's Disease, Courtesy Of A Special Yeast
Scientists identified several molecules capable of reversing the brain abnormalities of Parkinson's disease (PD), while also uncovering new clues for its origin in a study just published in the journal Disease Models and Mechanisms (1).
Parkinson's Patients Shed Light On Role Of Reward Bias In Compulsive Behaviors
New research unravels the brain mechanisms that underlie the ability of a standard drug treatment for Parkinson's to elicit compulsive behaviors in some patients with the disease. The study, published by Cell Press in the January 14th issue of the journal Neuron, provides fascinating new insight into the brain mechanisms that underlie a predisposition to behavioral addictions, such as pathological gambling and shopping.
The 'Noisiest' Neurons Persist In The Adult Brain
MIT neuroscientists have discovered that when it comes to new neurons in the adult brain, the squeakiest wheels get the grease."Before, scientists believed the cells with the most accurate performance were selected and the others were rejected," said Picower Institute for Learning and Memory researcher Carlos Lois.
Dual Role For Immune Cells In The Brain
We all have at one time or another experienced the typical signs of an infection: the fever, the listlessness, the lack of appetite. They are orchestrated by the brain in response to circulating cytokines, the signaling molecules of the immune system.
Reducing Dosage Of Parkinson's Drugs Can Cause Symptoms Similar To Those Of Cocaine Withdrawal
New research has shown that reducing the dosage of dopamine agonist (DA) drugs, a mainstay treatment for Parkinson's disease (PD), sometimes causes acute withdrawal symptoms similar to those reported by cocaine addicts -- including anxiety, panic attacks, depression, sweating, nausea, generalized pain, fatigue, dizziness and drug cravings.
NeurAxon Awarded Grant From The Michael J. Fox Foundation To Research Novel Treatment Approach For Parkinson's Disease
NeurAxon, Inc., a development-stage pharmaceutical company that is designing and developing next-generation pain therapeutics targeting neuronal nitric oxide synthase (nNOS), today announced that it has been awarded a grant of $267,000 from The Michael J.
Brain Scans Can Give Early Diagnosis Of Different Forms Of Parkinsonism
An article Online First and in the February edition of The Lancet Neurology reports that brain scans using positron emission tomography (PET) can identify with high accuracy which form of Parkinsonism a patient has.
VA Expected To Move Soon To Cover More Effects Of Agent Orange
The Department of Veterans Affairs may need to pay heavily to treat veterans who have been adversely affected by Agent Orange. McClatchy/Beaufort (S.C.) Gazette report: "The cost of war -- on veterans' health and taxpayer wallets -- will loom a little larger in the new year when the Department of Veterans Affairs issues a final rule to claim adjudicators to presume three more diseases of Vietnam veterans, including heart disease, were caused by exposure to Agent Orange.
More Brain Donors Needed For Parkinson's Research, UK
More brain donors are needed to help research into Parkinson's disease says a leading UK charity, and younger donors especially.Last week the Parkinson's Disease Society revealed that a campaign earlier this year has helped to more than double the number of donors on the Parkinson's Brain Donor Register, but more brains are still needed.
Small Molecules Found To Protect Cells In Multiple Models Of Parkinson's Disease
Several structurally similar small molecules appear capable of protecting cells from alpha-synuclein toxicity in multiple models of Parkinson's disease, according to Whitehead Institute researchers.
Abstinent Alcoholics And Postural Sway
Excessive sway during quiet standing is a common and significant consequence of chronic alcoholism, even after prolonged sobriety, and can lead to fall-related injury and even death. A new study of residual postural instability in alcohol-abstinent men and women shows that alcoholics improve with prolonged sobriety, but the improvement may not fully erase the problem of instability.
University Of Florida To Lead National Effort To Help Patients With Rare Brain Disease
Even with devastating brain diseases such as Alzheimer's and Parkinson's, doctors can reach into their medical bags to find something to help a patient. But they come up empty-handed when they try to help the vast majority of patients with ataxia - disabling disorders that rob people of their balance and coordination.
National Effort To Help Patients With Rare Brain Disease To Be Led By UF
When treating devastating brain diseases such as Alzheimer's and Parkinson's, doctors can reach into their medical bags to find something to help a patient.But they come up empty-handed when they try to help the vast majority of patients with ataxia - disabling disorders that rob people of their balance and coordination.
FDA Approves Newly Revised Prescribing Information For AZILECT(R) Reducing Medication And Food Restrictions
Teva Pharmaceutical Industries, Ltd. (NASDAQ: TEVA) announced the U.S. Food and Drug Administration (FDA) approved the newly revised prescribing information for AZILECT® (rasagiline tablets) reducing medication and food restrictions.
A Scaffold Regulating Protein Disposal Identified By MDC Researchers
How does a cell manage to identify and degrade the diverse types of defective proteins and thus protect the body against serious diseases?
Irregular Arm Swing May Point To Parkinson's Disease
Irregular arm swings while walking could be an early sign of Parkinson's disease, according to neurologists who believe early detection may help physicians apply treatments to slow further brain cell damage until strategies to slow disease progression are available.
Hope For New Parkinson's Disease Treatment Through RXR Activation
Following up on their previous work showing the rescue of dopamine neurons by chemicals that interact with the retinoid X receptor (RXR), researchers have now investigated the potential of these chemicals, known as RXR ligands, for the treatment of Parkinson's disease.
Irregular Arm Swing Could Be Early Sign Of Parkinson's
Neurologists in the US suggest irregular arm swings while walking could be an early sign of Parkinson's disease and scientific measurement of such a suspected symptom could help diagnose the disease earlier, giving greater opportunity to slow brain cell damage and disease progression.
Neurologix Completes All Surgical Procedures In Its Clinical Trial For Parkinson's Disease
Neurologix, Inc. (OTCBB:NRGX), a biotechnology company engaged in the development of innovative therapies for the brain and central nervous system, announced the completion of all planned surgeries in an ongoing Phase 2 clinical trial of the company's gene transfer approach to the treatment of advanced Parkinson's disease.
New Therapy Targets For Amyloid Disease
A major discovery is challenging accepted thinking about amyloids - the fibrous protein deposits associated with diseases such as Alzheimer's and Parkinson's - and may open up a potential new area for therapeutics.
Can Exercise Reduce The Symptoms Of Parkinson's Disease?
Officials at the new Muhammad Ali Parkinson Center at Barrow Neurological Institute announced today the center's participation in a novel Parkinson's study aimed at determining the physical and neurological impact of simple exercise on Parkinson's patients.
Stomach Hormone Can Boost Resistance To Or Slow Down Parkinson's, Study
US researchers report finding that ghrelin, a hormone produced in the stomach that regulates appetite and how the body deposits fat, may be used to boost resistance to or slow the development of Parkinson's disease.
Resistance To Parkinson's Disease Boosted By Hormone Ghrelin
Ghrelin, a hormone produced in the stomach, may be used to boost resistance to, or slow, the development of Parkinson's disease, Yale School of Medicine researchers report in a study published in a recent issue of the Journal of Neuroscience.
Johnson & Johnson Focused Funding Award Goes To Breakthrough Research Of Brain Cell Damage In Parkinson's Disease
Dr. Sarit Larisch, Head of the Cell Death Research Laboratory and senior lecturer at the University of Haifa, has been awarded the prestigious Johnson & Johnson Focused Funding grant for her research exploring the cause of brain cell damage in Parkinson's disease.
Addex ADX48621 Positive Primate Parkinson's Data
Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced that in a non-human primate model of Parkinson's disease (PD) levodopa induced dyskinesia (LID), ADX48621 statistically and significantly inhibited LID.
Science News From Weill Cornel: November 2009
Dr. Samie Jaffrey Receives Competitive NIH Director's T-R01 AwardSpeedier Lab Testing With Results That Glow in the DarkDr. Samie Jaffrey, associate professor of pharmacology at Weill Cornell Medical College, is among the first researchers to win a prestigious NIH Director's Transformative R01 award from the National Institutes of Health.
Grants From Michael J. Fox Foundation Awarded To BIDMC Scientists For Parkinson's Research
Beth Israel Deaconess Medical Center (BIDMC) neurologists Alvaro Pascual-Leone, MD, PhD, and Daniel Tarsy, MD, have been awarded grants totaling more than $1.5 million from the Michael J. Fox Foundation for Parkinson's Research (MJFF) to conduct investigations aimed at improving the quality of life for patients with Parkinson's disease.
Findings That Should Speed The Development Of Drugs For Parkinson's Disease
Australian scientists have significantly advanced our understanding of dopamine release from nerve cells, findings that should speed the development of more effective drugs for treating Parkinson's Disease.
Discovery Of Potential Drug Target For Neurological Diseases
A team of scientists at Cold Spring Harbor Laboratory (CSHL) report their success in solving the molecular structure of a key portion of a cellular receptor implicated in Alzheimer's, Parkinson's, and other serious illnesses.
Hope For Possible Parkinson's Disease Cure From ISU Researchers' Findings
Researchers at Iowa State University have found an essential key to possibly cure Parkinson's disease and are looking for others.Anumantha Kanthasamy, a distinguished professor of biomedical sciences and W.
Researchers Unlock The 'Sound Of Learning' By Linking Sensory And Motor Systems
Learning to talk also changes the way speech sounds are heard, according to a new study published in Proceedings of the National Academy of Sciences by scientists at Haskins Laboratories, a Yale-affiliated research laboratory.
Less Invasive Stereotactic Radiosurgery As Effective In Eliminating Parkinson's Disease Tremors As Other Treatments
Stereotactic radiosurgery (SRS) offers a less invasive way to eliminate tremors caused by Parkinson's disease and essential tremor than deep brain stimulation (DBS) and radiofrequency (RF) treatments, and is as effective, according to a long-term study presented November 2, 2009, at the 51st Annual Meeting of the American Society for Radiation Oncology (ASTRO).
Progression Of Parkinson's Disease May Be Prevented By Widely Used Cholesterol-Lowering Drug
Simvastatin, a commonly used, cholesterol-lowering drug, may prevent Parkinson's disease from progressing further. Neurological researchers at Rush University Medical Center conducted a study examining the use of the FDA-approved medication in mice with Parkinson's disease and found that the drug successfully reverses the biochemical, cellular and anatomical changes caused by the disease.
Brain Cell Transplants Help Repair Neural Damage In Mouse Model
A Swiss research team has found that using an animal's own brain cells (autologous transplant) to replace degenerated neurons in select brain areas of donor primates with simulated but asymptomatic Parkinson's disease and previously in a motor cortex lesion model, provides a degree of brain protection and may be useful in repairing brain lesions and restoring function.
Impax Pharmaceuticals Initiates Second Phase III Trial Of IPX066 In Parkinson's Disease
Impax Pharmaceuticals, the brand products division of Impax Laboratories, Inc. (NASDAQ:IPXL), announced that it has initiated a multinational Phase III trial of its late-stage drug candidate IPX066 in advanced Parkinson's disease (PD) patients.
Adult Eyes Cells Can Be Transformed Into Pluripotent Stem Cells Without Introducing Foreign Genetic Material
Scientists have overcome a key barrier to the clinical use of stem cells with a technique which transforms regular body cells into artificial stem cells without the need for introducing foreign genetic materials, which could be potentially harmful.
Study Conclusively Ties Rare Disease Gene To Parkinson's
An international team led by a National Institutes of Health researcher has found that carriers of a rare, genetic condition called Gaucher disease face a risk of developing Parkinson's disease more than five times greater than the general public.
Neural Stopwatch Found In The Brain
What's New: MIT researchers have identified populations of neurons that code time with extreme precision in the primate brain. These neurons are found in two interconnected brain regions, the prefrontal cortex and the striatum, both of which are known to play critical roles in learning, movement, and thought control.
New Research Highlighted At Neuroscience 2009
Research presented at Neuroscience 2009, the annual meeting of the Society for Neuroscience (SfN) and the world's largest source of emerging news about brain science and health, provides a better understanding of the brain, nervous system, and related disorders.
Mechanism For Neuron Self-Preservation Revealed By Researchers
Tsuruta et al. find that a lipid kinase directs a voltage-gated calcium channel's degradation to save neurons from a lethal dose of overexcitement. The study appears in the October 19, 2009 issue of the Journal of Cell Biology.
Early-Stage Parkinson's Study To Image Pre-Treatment Brain Function
Parkinson's disease, a debilitating movement disorder, is usually controlled by using drugs that compensate for a lack of the neurotransmitter dopamine. Parkinson's patients have a deficit of this important chemical because of degeneration in an area of the brain stem where it is made -- a structure called the substantia nigra.
MSU Becoming Center Of Excellence For Parkinson's Research
A team of researchers from Michigan State University and the University of Cincinnati have been awarded a $6.2 million Morris K. Udall Center of Excellence for Parkinson's disease grant.The grant, from the National Institute for Neurological Disorders and Stroke at the National Institutes of Health, makes MSU's College of Human Medicine a major player in research of the degenerative disease.
Rochester-Led Parkinson's Study Pays Off Again, 2 Decades Later
Parkinson disease progresses more slowly in patients who have higher levels of urate, a chemical that at very high level is associated with gout, scientists have found. While it's unknown whether the high levels actually somehow protect patients or simply serve as a marker of protection, the finding supports the idea that patients and doctors may one day be able to better predict the course of the illness.
Phosphorylation Of Alpha-synuclein - A Balancing Act In Parkinson's Disease
Both genetic and pathologic data indicate a role for the neuronal protein alpha-synuclein in Parkinson disease. Previous studies have indicated that phosphorylation of alpha-synuclein at amino acid 129 (Ser129) is a key event in alpha-synuclein-mediated nerve cell toxicity.
Urate In Blood And Spinal Fluid May Predict Slower Decline In Patients With Parkinson's Disease
Higher concentration of urate (an antioxidant) in the blood and spinal fluid of patients with early Parkinson's disease is associated with slower rates of clinical decline, according to a report posted online today that will appear in the December print issue of Archives of Neurology, one of the JAMA/Archives journals.
Gene Therapy Study For Parkinson's Disease Launched By Michigan Hospital
A Michigan hospital is embarking on a research study for advanced Parkinson's disease using a state-of-the-art treatment called gene transfer.The clinical trial will test whether gene transfer therapy is able to restore better mobility in Parkinson's patients who have lost responsiveness to drug therapy.
Henry Ford West Bloomfield Hospital Launches Gene Therapy Study For Parkinson's Disease
Henry Ford West Bloomfield Hospital is embarking on a research study for advanced Parkinson's disease using a state-of-the-art treatment called gene transfer.The clinical trial will test whether gene transfer therapy is able to restore better mobility in Parkinson's patients who have lost responsiveness to drug therapy.
Pico-Tesla Starts Phase III Clinical Trial Of Its Proprietary Magnetic (Magneceutical™) Therapy For Parkinson's Disease
Pico-Tesla, The Magneceutical™ Therapy Company, announced today that it has commenced a Phase III clinical trial of its patented Resonator™ system that facilitates the Company's proprietary magnetic (Magneceutical™) therapy for treating Parkinson's disease patients.
Drivers With Parkinson's Disease At Higher Risk Of Crashes In Low Visibility
Drivers with mild to moderate Parkinson's disease may be at higher risk of crashes on foggy days and other times of low visibility. The research, involving a driving simulation test, is published in the October 6, 2009, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Cholesterol Important For Brain Development, Study
A new study by an international team of researchers found that cholesterol is important for the formation of brain cells, and they hope the findings will help scientists cultivate dopamine-producing cells outside the body.
Special Brain Wave Boost Slows Motion
Researchers have found that they can make people move in slow motion by boosting one type of brain wave. The findings offer some of the first proof that brain waves can have a direct influence on behavior, according to the researchers, who report their findings online on October 1 in Current Biology, a Cell Press publication.
Conducting Polymer Nanotubes Take Us A Step Closer To Better Brain Implants
Brain implants that can more clearly record signals from surrounding neurons in rats have been created at the University of Michigan. The findings could eventually lead to more effective treatment of neurological disorders such as Parkinson's disease and paralysis.
Increase In Alzheimer's Plaques And Sleep Loss Linked
Chronic sleep deprivation in a mouse model of Alzheimer's disease makes Alzheimer's brain plaques appear earlier and more often, researchers at Washington University School of Medicine in St.
Results Of ADAGIO Study With AZILECT(R) In Parkinson's Disease Published In New England Journal Of Medicine
Results from the ADAGIO trial, published online today in The New England Journal of Medicine, demonstrated that Parkinson's disease patients receiving AZILECT® (rasagiline) 1mg/day at the start of the study (early-start group) experienced superior benefit over 18 months compared with those who started the exact same treatment nine months later (delayed-start group).
Drug Might Slow Parkinson's Disease Progression
Following one of the largest studies ever conducted in Parkinson's disease (PD), researchers at Mount Sinai School of Medicine report in The New England Journal of Medicine that rasagiline, a drug currently used to treat the symptoms of PD, may also slow the rate of disease progression.
New Insight Into Age-Related Muscle Decline
If you think the air outside is polluted, a new research report in the September 2009 issue of the journal Genetics might make you to think twice about the air inside our bodies too. That's because researchers show how about 3 percent of the air we breathe gets converted into harmful superoxides, which ultimately harm our muscles.
Impax Pharmaceuticals Reports Positive Results Of Phase II Trial Of IPX066, A Novel Formulation Of Carbidopa-Levodopa For Parkinson's Disease
Impax Pharmaceuticals, the brand products division of Impax Laboratories, Inc. (NASDAQ: IPXL) reported the positive results from a recently completed Phase II trial of its late-stage Parkinson's Disease drug candidate IPX066 In this cross-over trial, IPX066 reduced subjects' "off" time during waking hours by 2 hours compared to Sinemet (3.
Can An Over-the-Counter Vitamin-Like Substance Slow The Progression Of Parkinson's Disease?
Rush University Medical Center is participating in a large-scale, multi-center clinical trial in the U.S. and Canada to determine whether a vitamin-like substance, in high doses, can slow the progression of Parkinson's disease, a neurodegenerative disorder that affects about one million people in the United States.
Success For The European Federation Of Neurological Associations 'Good Life' Symposium
The European Federation of Neurological Associations (EFNA) celebrated the success of its 'Good Life' symposium at the European Federation of Neurological Societies (EFNS) conference in Florence last weekend.
On-the-Job Pesticide Exposure Associated With Parkinson's Disease
Individuals whose occupation involves contact with pesticides appear to have an increased risk of having Parkinson's disease, according to a report in the September issue of Archives of Neurology, one of the JAMA/Archives journals.
Proving That Scary Music Is Scarier With Your Eyes Shut Could Lead To New Neurological Treatments
The power of the imagination is well-known: it's no surprise that scary music is scarier with your eyes closed. But now neuroscientist and psychiatrist Prof. Talma Hendler of Tel Aviv University's Functional Brain Center says that this phenomenon may open the door to a new way of treating people with Alzheimer's, Parkinson's and other neurological diseases.
Occupational Chemical Exposure Associated With Parkinson's Disease
A report in the September issue of Archives of Neurology (one of the JAMA/Archives journals) shows that individuals whose occupation involves contact with pesticides appear to have an increased risk of having Parkinson's disease.
Addex' ADX10059 Has Potential For Parkinson's Disease Levodopa Induced Dyskinesia (PD-LID)
Allosteric modulation company Addex Pharmaceuticals (SWISS: ADXN) reported that its lead product, ADX10059, which is nearing completion of Phase IIb testing in gastroesophageal reflux disease (GERD) and migraine prevention, also has demonstrated significant potential in a non-human primate model of Parkinson's disease levodopa induced dyskinesia (PD-LID).
Thomas Hobbes' Parkinsonism
The English philosopher, Thomas Hobbes (1588-1679), is best known for his political philosophy, although during his day he was more widely known as a scientist, a mathematician, a translator of...read more
Mitochondria And Parkinson's Disease
Some forms of familial Parkinson's disease are linked to loss of function of the genes called Parkin, or PINK1, but, until recently, it was not understood why. Why did these...read more
Sexuality and Relationships in Young Onset Parkinson's Disease
People with young onset forms of Parkinson's disease (PD) face unique challenges;- among them raising children and maintaining partnerships and relationships while coping with a progressive and chronic illness....read more
St. Jude Medical Receives CE Mark Approval For World's Smallest, Longest-Lasting Rechargeable Deep Brain Stimulator For Parkinson's Disease
St. Jude Medical, Inc. (NYSE:STJ) announced CE (ConformitÃ© EuropÃ©enne) Mark approval of the Brio™ neurostimulator, the world's smallest, longest-lasting rechargeable deep brain stimulation (DBS) device for treating the symptoms of Parkinson's disease.
Transgenomic And Power3 Medical Report Identification Of Abnormal Serum Proteins In Parkinson's Disease
Transgenomic, Inc. (OTC Bulletin Board: TBIO) and Power3 Medical Products, Inc. (OTC Bulletin Board: PWRM) announced the advance on-line publication of a clinical research paper entitled "Abnormal Serum Concentrations of Proteins in Parkinson's Disease" in the scientific journal Biochemical and Biophysical Research Communications.
Nerve Growth Factor With Therapeutic Potential In Parkinson's Disease Discovered By Finnish Scientists
Scientists in the Academy of Finland's Neuroscience Research Programme have reported promising new results with potential implications for the treatment of Parkinson's disease. They have been studying the impacts of nerve growth factors in the treatment of PD, and their latest results show that a certain growth factor can be used to halt the progress of damage brought on by a nerve poison and possibly even restore the function of damaged cells.
Acupuncture for Parkinson's Disease?
For years now there have been reports that acupuncture improves Parkinson's disease symptoms including body posture, tremor, and rigidity. Now a recent study in the journal Movement Disorders demonstrates that...read more
Modafinil to Treat Fatigue in Parkinson's Disease
Fatigue is a major nonmotor symptom in Parkinson disease (PD) and undermines efforts at coping with the disease. At present there are no known effective treatments for fatigue in PD....read more
Scientists Construct 'Off Switch' For Parkinson Therapy
A common antibiotic can function as an "off switch" for a gene therapy being developed for Parkinson's disease, according to University of Florida researchers writing online in advance of September's Molecular Therapy.
Researchers Pinpoint Neural Nanoblockers In Carbon Nanotubes
Carbon nanotubes hold many exciting possibilities, some of them in the realm of the human nervous system. Recent research has shown that carbon nanotubes may help regrow nerve tissue or ferry drugs used to repair damaged neurons associated with disorders such as epilepsy, Parkinson's disease and perhaps even paralysis.
New Technology Helps Parkinson's Patients Speak Louder
Researchers have developed a new technology that helps Parkinson's patients overcome the tendency to speak too quietly by playing a recording of ambient sound, which resembles the noisy chatter of a restaurant full of patrons.
$1 Million To Spur Novel Research Of High Importance To Understanding Aging And Its Impact On Diseases Of Aging
Charleen T. Chu, MD, PhD, associate professor at the University of Pittsburgh and David M. Sabatini, MD, PhD, associate professor, Massachusetts Institute of Technology received the 2009 Julie Martin Mid-Career Awards in Aging Research.
When Cells Run Out Of Fuel Parkinson Genes Ensure The Energy Supply Of Neurons
Parkinson's disease is caused by the degeneration of neurons in the midbrain. The mechanisms leading to the loss of these neurons, however, are largely unknown. Recent research revealed that about ten per cent of cases are caused by defects in so-called Parkinson-associated genes.
Biovail To Acquire Rights To Develop, Commercialize JP-1730/Fipamezole In North America From Santhera
Biovail Corporation (NYSE:BVF) (TSX:BVF) announced that its subsidiary, Biovail Laboratories International SRL (BLS), has entered into an agreement with Santhera Pharmaceuticals (Switzerland) Ltd.
Insight Into How Stems Cells Develop Into Other Types Of Cells
Scientists have uncovered a vital link in the chain of events that gives stem cells their remarkable properties.Researchers from the Wellcome Trust Centre for Stem Cell Research at the University of Cambridge have pinpointed the final step in a complex process that gives embryonic stem cells their unique ability to develop into any of the different types of cells in the body (from liver cells to skin cells).
Housekeeping Gene Study Impacts Lesch Nyhan & Parkinson's
A study from the Center for Molecular Genetics at the University of California, San Diego School of Medicine shows that a gene called HPRT plays an important role in setting the program by which primitive or precursor cells decide to become normal nerve cells in the human brain.
Impax Pharmaceuticals Selects OmniComm Systems To Provide EClinical Solutions For International Phase III Study In Parkinson's Disease
OmniComm Systems, Inc. (OTC Bulletin Board: OMCM), one of the fastest growing companies in the EDC marketplace, announced that Impax Pharmaceuticals, the brand division of Impax Laboratories, Inc.
Viability Of Bone Marrow Stem Cells With Unique MRI Tracking Methods Shown By TAU Researcher
There is no known cure for neurodegenerative diseases such as Huntington's, Alzheimer's and Parkinson's. But new hope, in the form of stem cells created from the patient's own bone marrow, can be found - and literally seen - in laboratories at Tel Aviv University.
Seeking New Smoking Cessation Target
The National Institutes of Health (NIH) has awarded a scientist at the Barrow Neurological Institute at St. Joseph's Hospital and Medical Center a $275,000 grant to study a rare brain receptor that may be a new smoking cessation target.
Parkinson's Disease: Iron Accumulation To The Point Of Demise
Investigation of the human brain discloses a distinct dark discoloration of the substantia nigra and locus coeruleus within parts of the brainstem. This is due to the bluish to brown-black pigment neuromelanin, which is only present in the human brain and that of a few other mammals (primates, cows, horses, some breeds of sheep).
Davis Phinney Foundation Announces New U.S. Study To Evaluate The Long-Term Physical And Emotional Effects Of Parkinson's Disease.
The Davis Phinney Foundation, a non-profit organization dedicated to improving the lives of people with Parkinson's disease (PD), has announced that it has awarded four Parkinson's disease research centers with support to conduct a landmark study on the long-term changes in quality of life and mobility that occur in people with PD.
UH Awarded Lead Role By EPA To Study Toxin Effects On Embryonic Development
Most people would agree that arsenic, lead, mercury, benzene and carbon monoxide pose dangers to humans. Not many, though, realize that the average person is exposed to about 10,000 different chemicals per day.
Recruitment Of New Neurons Slows When Old Brain Cells Kept From Dying
Like clockwork, brain regions in many songbird species expand and shrink seasonally in response to hormones. Now, for the first time, University of Washington neurobiologists have interrupted this natural "annual remodeling" of the brain and have shown that there is a direct link between the death of old neurons and their replacement by newly born ones in a living vertebrate.
Depomed Reports Encouraging Results Of Its Phase I Trial For DM-1992 Program In Parkinson's Disease
Depomed, Inc. (NASDAQ:DEPO) today announced that in its Phase 1 pharmacokinetic study in Parkinson's patients, DM-1992, Depomed's investigative novel gastric retentive extended-release formulation of levodopa/carbidopa, extended coverage above levodopa's efficacious threshold and extended the time to peak levodopa concentration relative to currently available sustained release levodopa/carbidopa formulations.
Diverse Methods Yield Clues In Protein Folding
Rice University physicists have written the next chapter in an innovative approach for studying the forces that shape proteins -- the biochemical workhorses of all living things.New research featured on the cover of the Journal of Physical Chemistry illustrates the value of studying proteins with a new method that uses the tools of nanotechnology to grab a single molecule and pull it apart.
Eye Movements Of Parkinson's Disease Patients During Sentence Comprehension Support Subcortical Role In Processing Syntax
The study of the neural basis of language has largely focused on regions in the cortex - the outer brain layers thought by many researchers to have expanded during human evolution. Research at Brown University's Department of Cognitive and Linguistic Sciences, reported in the September Issue of Cortex, published by Elsevier, adds to evidence that deeper, subcortical regions are also critical by pinpointing when Parkinson's disease patients have difficulty while processing grammatically complex sentences.
Dystonia: Abnormal Brain Circuits May Prevent Movement Disorder
Specific changes in brain pathways may counteract genetic mutations for the movement disorder dystonia, according to new research in the August 5 issue of The Journal of Neuroscience. Few people who inherit dystonia genes display symptoms - namely sustained muscle contractions and involuntary gestures - and the study provides a possible explanation.
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